Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.66 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826184 | 1.00 | APP (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826833 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10825852 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826117 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826115 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10825853 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826836 | 0.95 | KDM4E (0.66) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826116 | 0.93 | KDM4E (0.67) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL10826118 | 0.93 | KDM4E (0.67) | APPTOP2AALOX5HPGDKDM4E | |
| SCHEMBL8162302 | 0.90 | ALOX5 (0.76) | APPALOX5HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4618627-A | ALLERGIES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-21 | — | — | US | disclosed |
| EP-0125919-A2 | Catechol derivatives, their production and intermediates therefor, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1984-11-21 | — | — | EP | disclosed |