Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430124 | 0.76 | ALDH1A1 (0.47) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9711551 | 0.73 | GAA (0.48) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11970774 | 0.71 | ALDH1A1 (0.59) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5598729 | 0.71 | ALDH1A1 (0.59) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5386997 | 0.70 | MAPT (0.59) | ALDH1A1TSHRBRD4KMT2ASMN1; SMN2 | |
| SCHEMBL17619382 | 0.69 | CHRNA7 (0.48) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL15846794 | 0.69 | BRD4 (0.42) | ALDH1A1TSHRBRD4KMT2AMEN1 | |
| SCHEMBL1240108 | 0.69 | KDM4E (0.54) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1419218 | 0.68 | ALDH1A1 (0.49) | ALDH1A1TSHRKMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL10827450 | 0.68 | LMNA (0.48) | ALDH1A1ATMCHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4625028-A | 6-aryluracils and selected novel intermediates used in the preparation thereof | THE UPJOHN COMPANY (US) | 1986-11-25 | — | — | US | disclosed |
| US-4593030-A | Use of 6-aryluracils as antiinflammatory and antiarthritic agents | THE UPJOHN COMPANY (US) | 1986-06-03 | — | — | US | disclosed |
| US-4578466-A | Processes for the preparation of 6-aryluracils | THE UPJOHN COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| US-4521599-A | Process for the preparation of 1,3-oxazine-4-ones | THE UPJOHN COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| US-4495349-A | 6-Aryluracils | THE UPJOHN COMPANY (US) | 1985-01-22 | — | — | US | disclosed |