Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10830240 | 0.84 | CACNA1F (0.47) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL10830282 | 0.80 | ADORA3 (0.45) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL10830235 | 0.68 | TSHR (0.59) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL10830305 | 0.66 | KDM4E (0.60) | ADORA3KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7377459 | 0.66 | KDM4E (0.51) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL10950737 | 0.62 | ALDH1A1 (0.52) | ADORA3ALDH1A1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7434340 | 0.59 | ADORA3 (0.62) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL7245896 | 0.59 | ADORA3 (0.57) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL8915432 | 0.58 | ALDH1A1 (0.36) | KDM4EALDH1A1HSD17B10MEN1HPGD | |
| SCHEMBL10830287 | 0.57 | HSD17B10 (0.44) | ADORA3KDM4EALDH1A1SMN1; SMN2CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567268-A | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |