Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831601 | 0.91 | BRD4 (0.36) | TLR8TLR7TLR9BRD4BRD2 | |
| SCHEMBL11089655 | 0.90 | TLR9 (0.37) | TLR8TLR7TLR9BRD4BRD2 | |
| SCHEMBL10951508 | 0.89 | HTR2A (0.38) | TLR8TLR7TLR9BRD4HTR2A | |
| SCHEMBL4983559 | 0.87 | BRD4 (0.35) | BRD4BRD2BRD3HTR2AHTR2C | |
| SCHEMBL10832147 | 0.87 | ALDH1A1 (0.40) | BRD4BRD2BRD3HTR2AHTR2C | |
| SCHEMBL10956084 | 0.84 | TLR8 (0.34) | TLR8TLR7TLR9BRD4BRD2 | |
| SCHEMBL10950276 | 0.83 | TLR9 (0.37) | TLR8TLR7TLR9BRD4 | |
| SCHEMBL10831728 | 0.82 | BRD4 (0.34) | TLR8TLR7TLR9BRD4BRD2 | |
| SCHEMBL11087615 | 0.79 | BRD4 (0.39) | TLR8TLR7TLR9BRD4HTR2A | |
| SCHEMBL10954061 | 0.79 | KCNH2 (0.34) | HTR2AHTR2CGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | claimed |
| US-4582848-A | 2-substituted-3-indolamines and use thereof as anti-diabetics | SANDOZ, INC. (US) | 1986-04-15 | — | — | US | disclosed |
| US-4544663-A | ASPERMATOGENESIS INDUCERS | SANDOZ, INC. (US) | 1985-10-01 | — | — | US | disclosed |
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |