Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954061 | 0.92 | KCNH2 (0.34) | MAPTKCNH2HDAC1CYP3A4CYP1A2 | |
| SCHEMBL10951684 | 0.90 | CYP1A2 (0.36) | BRD4BRD2BRD3MAPTKCNH2 | |
| SCHEMBL10831601 | 0.89 | BRD4 (0.36) | BRD4BRD2BRD3MAPTCYP1A2 | |
| SCHEMBL10831913 | 0.89 | HTR6 (0.35) | BRD4BRD2BRD3MAPTKCNH2 | |
| SCHEMBL10956105 | 0.89 | BRD4 (0.35) | BRD4BRD2BRD3MAPTCYP3A4 | |
| SCHEMBL10956410 | 0.88 | KCNH2 (0.40) | BRD4BRD2BRD3MAPTKCNH2 | |
| SCHEMBL10954868 | 0.87 | CCNB2 (0.32) | — | |
| SCHEMBL10831731 | 0.87 | TLR8 (0.34) | BRD4BRD2BRD3KIF11NPC1 | |
| SCHEMBL10949640 | 0.86 | MEN1 (0.30) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10832147 | 0.85 | ALDH1A1 (0.40) | BRD4BRD2BRD3MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446121-A4 | DIINDOLYLMETHANE FOR THE TREATMENT OF HPV INFECTION | BIORESPONSE LLC (US) | 2007-02-21 | — | — | EP | claimed |
| EP-1446121-A2 | DIINDOLYLMETHANE FOR THE TREATMENT OF HPV INFECTION | Bioresponse, L.L.C. (US) | 2004-08-18 | — | — | EP | claimed |
| WO-2003034992-A2 | DIINDOLYLMETHANE FOR THE TREATMENT OF HPV INFECTION | BIORESPONSE, L.L.C. (US) | 2003-05-01 | — | — | WO | claimed |
| US-4544663-A | ASPERMATOGENESIS INDUCERS | SANDOZ, INC. (US) | 1985-10-01 | — | — | US | claimed |
| EP-0038298-B1 | ISOXAZOLYL INDOLAMINES | SANDOZ AG (CH) | 1984-07-25 | — | — | EP | claimed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | claimed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | claimed |
| EP-0038298-A1 | Isoxazolyl indolamines | SANDOZ AG (CH) | 1981-10-21 | — | — | EP | claimed |
| US-8236848-B2 | Along with a concentrate of Aloe Vera and a carrier; suspension as microparticles in a starch carrier matrix; including an immunopotentiating steroid; to treat warts and human papilloma virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix; oral, topical administration | BIORESPONSE, L.L.C. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20080145418-A1 | Diindolylmethane for the treatment of HPV infection | BIORESPONSE L.L.C., | 2008-06-19 | — | — | US | disclosed |
| US-7348352-B2 | Diindolylmethane for the treatment of HPV infection | BIORESPONSE L.L.C. (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1446121-A4 | DIINDOLYLMETHANE FOR THE TREATMENT OF HPV INFECTION | BIORESPONSE LLC (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1446121-A2 | DIINDOLYLMETHANE FOR THE TREATMENT OF HPV INFECTION | Bioresponse, L.L.C. (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030096855-A1 | Diindolylmethane for the treatment of HPV infection | BIORESPONSE L.L.C. | 2003-05-22 | — | — | US | disclosed |
| US-4582848-A | 2-substituted-3-indolamines and use thereof as anti-diabetics | SANDOZ, INC. (US) | 1986-04-15 | — | — | US | disclosed |
| US-4544663-A | ASPERMATOGENESIS INDUCERS | SANDOZ, INC. (US) | 1985-10-01 | — | — | US | disclosed |
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |
| EP-0038298-A1 | Isoxazolyl indolamines | SANDOZ AG (CH) | 1981-10-21 | — | — | EP | disclosed |