Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 12/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.37 |
| ▸ | MPO | P05164 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831731 | 0.90 | TLR8 (0.34) | TLR9TLR8TLR7BRD4BRD2 | |
| SCHEMBL11087615 | 0.89 | BRD4 (0.39) | TLR9TLR8TLR7MPOBRD4 | |
| SCHEMBL10831913 | 0.87 | HTR6 (0.35) | TLR9TLR8TLR7MPOBRD4 | |
| SCHEMBL10832528 | 0.84 | KMT2A (0.41) | TLR9TLR8TLR7 | |
| SCHEMBL10950276 | 0.81 | TLR9 (0.37) | TLR9TLR8TLR7BRD4 | |
| SCHEMBL10831601 | 0.81 | BRD4 (0.36) | TLR9TLR8TLR7BRD4BRD2 | |
| SCHEMBL10831728 | 0.81 | BRD4 (0.34) | TLR9TLR8TLR7BRD4BRD2 | |
| SCHEMBL11086175 | 0.80 | GABRA1 (0.39) | TLR9TLR8TLR7BRD4 | |
| SCHEMBL10951508 | 0.79 | HTR2A (0.38) | TLR9TLR8TLR7BRD4 | |
| SCHEMBL10832147 | 0.77 | ALDH1A1 (0.40) | BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4467096-A | ANTIDIABETIC AGENTS, INTERMEDIATES THEREFOR | SANDOZ, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4421752-A | ANTIDIABETIC AGENT | SANDOZ, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4336391-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |