Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | EPHB3 | P54753 | 5/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17967746 | 0.90 | EPHB3 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17867589 | 0.85 | NPC1 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30321099 | 0.83 | NPC1 (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1286674 | 0.81 | NPC1 (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3457843 | 0.80 | ALDH1A1 (0.59) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL416200 | 0.80 | EPHB3 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11300658 | 0.78 | EPHB3 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL30152645 | 0.78 | EPHB3 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL19119427 | 0.78 | EPHB3 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1044120 | 0.78 | EPHB3 (0.58) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4604400-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1986-08-05 | — | — | US | claimed |
| EP-3286185-A1 | SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-2791139-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-11-08 | — | — | EP | disclosed |
| US-9422285-B2 | Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-08-23 | — | — | US | disclosed |
| WO-2016124565-A1 | SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-08-11 | — | — | WO | disclosed |
| US-20160185775-A1 | SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-30 | — | — | US | disclosed |
| EP-2791139-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | Dr. Reddy's Laboratories Ltd. (IN) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013088257-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-06-20 | — | — | WO | disclosed |
| US-4604400-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1986-08-05 | — | — | US | disclosed |
| US-4604400-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1986-08-05 | — | — | US | disclosed |
| US-4604400-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1986-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185775-A1 | SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF | PC, AADAC, PDXK | NPC1 1781/4885RAB9A 3735/4885ALDH1A1 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.