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Methylene Chloride

Methylene Chloride

SCHEMBL10834874

Cc1ccc2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)ccc2c1.ClCCl

nearest known ligand 0.56

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Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ RARA P10276 17/20 0.56
▸ RARB P10826 17/20 0.56
▸ RARG P13631 16/20 0.56
▸ RXRA P19793 3/20 0.42
▸ CYP26A1 O43174 1/20 0.40
▸ CYP26B1 Q9NR63 1/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ CYP2A6 P11509 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10834799 0.94 RARA (0.61) RARARARBRARGRXRACYP26A1
SCHEMBL8900020 0.79 RARB (0.65) RARARARBRARGRXRACYP26A1
SCHEMBL9359619 0.79 RARB (0.63) RARARARBRARGRXRACYP26A1
SCHEMBL10834419 0.76 RARA (0.64) RARARARBRARGRXRACYP26A1
SCHEMBL1615553 0.76 RXRA (0.46) RARARARBRARGRXRACYP26A1
SCHEMBL29606831 0.76 RXRA (0.46) RARARARBRARGRXRACYP26A1
SCHEMBL10834477 0.76 RARB (0.59) RARARARBRARGRXRACYP26A1
SCHEMBL26151172 0.75 RARB (0.54) RARARARBRARGRXRA
Methane SCHEMBL10834484 0.75 RARA (0.62) RARARARBRARGRXRACYP26A1
SCHEMBL10835377 0.73 RARA (0.60) RARARARBRARGRXRACYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4581380-A TREATMENT OF SKIN DISORDERS;ANTIINFLAMMATORY AGENTS Groupement Economique dite: Centre National de Recherches Dermatologiques C.I.R.D. (FR) 1986-04-08 — — US disclosed