Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10836211 | 1.00 | TBXAS1 (0.56) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL10838022 | 0.90 | TBXAS1 (0.52) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL10838028 | 0.90 | TBXAS1 (0.52) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL31590987 | 0.78 | PDE3B (0.53) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL3952072 | 0.78 | PDE3B (0.53) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL6963342 | 0.78 | TBXAS1 (0.67) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL6963344 | 0.78 | TBXAS1 (0.67) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL5534848 | 0.77 | PDE3B (0.50) | TBXAS1PDE3BPDE3ACRBNCYP11B1 | |
| SCHEMBL10837487 | 0.77 | MAOA (0.51) | TBXAS1PDE3BPDE3ACRBNMAOA | |
| SCHEMBL10463488 | 0.77 | TBXAS1 (0.65) | TBXAS1PDE3BPDE3ACRBNCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |