Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837209 | 0.95 | DRD2 (0.57) | DRD2HTR1AHTR2AALDH1A1LMNA | |
| SCHEMBL10836576 | 0.86 | DRD2 (0.59) | DRD2HTR1AHTR2AMAPTKCNH2 | |
| SCHEMBL10837291 | 0.82 | DRD2 (0.57) | DRD2HTR1AHTR2AALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL10835891 | 0.82 | DRD2 (0.64) | DRD2HTR1AHTR2AALDH1A1LMNA | |
| SCHEMBL10837913 | 0.81 | DRD2 (0.53) | DRD2HTR1AHTR2ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10836347 | 0.81 | DRD2 (0.67) | DRD2HTR1AHTR2AALDH1A1LMNA | |
| SCHEMBL10837721 | 0.80 | HTR1A (0.65) | DRD2HTR1AALOX15DRD4DRD3 | |
| SCHEMBL10835827 | 0.79 | DRD2 (0.51) | DRD2HTR1AHTR2AALDH1A1KCNH2 | |
| Hydrochloric Acid SCHEMBL10837752 | 0.79 | DRD2 (0.57) | DRD2HTR1AHTR2AALDH1A1LMNA | |
| SCHEMBL10835956 | 0.78 | KCNH2 (0.50) | DRD2HTR1AHTR2AALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |