Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.59 |
| ▸ | HTR1A | P08908 | 8/20 | 0.59 |
| ▸ | HTR2A | P28223 | 6/20 | 0.59 |
| ▸ | DRD4 | P21917 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | DRD1 | P21728 | 2/20 | 0.52 |
| ▸ | DRD5 | P21918 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MLNR | O43193 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837291 | 0.87 | DRD2 (0.57) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10837489 | 0.86 | DRD2 (0.61) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10837913 | 0.85 | DRD2 (0.53) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10837721 | 0.82 | HTR1A (0.65) | DRD2HTR1ADRD4DRD3 | |
| SCHEMBL10836282 | 0.82 | ALDH1A1 (0.56) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10835827 | 0.81 | DRD2 (0.51) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10837085 | 0.81 | DRD2 (0.69) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL10837209 | 0.81 | DRD2 (0.57) | DRD2HTR1AHTR2AKCNH2MAPT | |
| SCHEMBL23097785 | 0.80 | DRD2 (0.82) | DRD2HTR1AHTR2ADRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10838709 | 0.80 | HTR1A (0.69) | DRD2HTR1AHTR2ADRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |