Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | HEXA | P06865 | 1/20 | 0.42 |
| ▸ | HEXB | P07686 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16087635 | 0.80 | RPS6KA2 (0.56) | RPS6KA2GLSMEN1KMT2AMAPT | |
| SCHEMBL3062593 | 0.76 | RPS6KA2 (0.73) | RPS6KA2KMT2APOLBALDH1A1HPGD | |
| SCHEMBL8436723 | 0.73 | CASP3 (0.57) | GLSMEN1KMT2APOLBCASP1 | |
| SCHEMBL805142 | 0.73 | OGA (0.70) | GLSOGAHEXAHEXBSMN1; SMN2 | |
| SCHEMBL2754749 | 0.72 | RAB9A (0.55) | RPS6KA2GLSMEN1KMT2APOLB | |
| SCHEMBL11237861 | 0.72 | CYP1A2 (0.57) | RPS6KA2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL10819269 | 0.72 | RPS6KA2 (0.74) | RPS6KA2MEN1KMT2APOLBHEXA | |
| SCHEMBL28776422 | 0.71 | CES1 (0.60) | RPS6KA2MEN1KMT2APOLBHEXA | |
| SCHEMBL7973833 | 0.71 | OGA (0.68) | GLSOGAHEXAHEXBSMN1; SMN2 | |
| SCHEMBL6699936 | 0.70 | GLS (0.71) | GLSMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |