Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 12/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837830 | 1.00 | LMNA (0.58) | LMNAHTTSMN1; SMN2DRD2TSHR | |
| SCHEMBL10836599 | 0.89 | DRD2 (0.55) | LMNAHTTSMN1; SMN2DRD2HTR1A | |
| SCHEMBL10836603 | 0.89 | DRD2 (0.55) | LMNAHTTSMN1; SMN2DRD2HTR1A | |
| SCHEMBL10835811 | 0.88 | DRD2 (0.46) | LMNAHTTSMN1; SMN2DRD2HTR1A | |
| SCHEMBL10835817 | 0.88 | DRD2 (0.46) | LMNAHTTSMN1; SMN2DRD2HTR1A | |
| SCHEMBL10838095 | 0.85 | ALOX15 (0.58) | HTTDRD2TSHRDRD4DRD3 | |
| SCHEMBL10838101 | 0.85 | ALOX15 (0.58) | HTTDRD2TSHRDRD4DRD3 | |
| SCHEMBL10837548 | 0.85 | DRD2 (0.50) | DRD2HTR1AHTR2ATBXAS1PDE3B | |
| SCHEMBL10837555 | 0.85 | DRD2 (0.50) | DRD2HTR1AHTR2ATBXAS1PDE3B | |
| SCHEMBL10837911 | 0.84 | KDM4E (0.60) | HTTDRD2TSHRDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |