Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494871 | 0.79 | KMT2A (0.58) | NPC1RAB9AKMT2ARHOAAURKA | |
| SCHEMBL4812645 | 0.79 | NCF1 (0.53) | NPC1RAB9AKMT2ARHOAMAPT | |
| SCHEMBL27960243 | 0.78 | RHOA (0.55) | NPC1RAB9AKMT2ARHOAAURKA | |
| SCHEMBL29833517 | 0.78 | NCF1 (0.61) | ROCK1NPC1RAB9AKMT2ARHOA | |
| SCHEMBL396525 | 0.78 | NCF1 (0.61) | ROCK1NPC1RAB9AKMT2ARHOA | |
| SCHEMBL11566043 | 0.77 | GRM5 (0.60) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL30534868 | 0.77 | DNMT1 (0.59) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL21446750 | 0.77 | RAB9A (0.73) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9965273 | 0.76 | NPC1 (0.64) | ROCK1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL29110577 | 0.76 | NPC1 (0.58) | NPC1RAB9AKMT2ARHOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4610991-A | Antihypertensive pyridylaminobenzamide compounds | STERLING DRUG INC. (US) | 1986-09-09 | — | — | US | disclosed |
| EP-0098951-A2 | Aminobenzamide derivatives and preparation thereof | STERLING DRUG INC. (US) | 1984-01-25 | — | — | EP | disclosed |