Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838725 | 1.00 | POLB (0.43) | POLBHRH1SLC22A8CYP2C19MAPK1 | |
| SCHEMBL10838952 | 0.88 | POLB (0.43) | POLBMAPK1EPHX2SIGMAR1SMN1; SMN2 | |
| SCHEMBL10838937 | 0.88 | POLB (0.43) | POLBMAPK1EPHX2SIGMAR1SMN1; SMN2 | |
| SCHEMBL10838533 | 0.84 | STS (0.52) | POLBCYP3A4GAA | |
| SCHEMBL10838527 | 0.84 | STS (0.52) | POLBCYP3A4GAA | |
| SCHEMBL10836705 | 0.84 | CA12 (0.46) | GAA | |
| SCHEMBL10836698 | 0.84 | CA12 (0.46) | GAA | |
| SCHEMBL10547616 | 0.79 | GAPDH (0.40) | — | |
| SCHEMBL10413872 | 0.78 | MAPK1 (0.38) | POLBHRH1SLC22A8CYP2C19MAPK1 | |
| SCHEMBL10548246 | 0.78 | GAPDH (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062876-B1 | 2-OXO-1-(((SUBSTITUTED SULFONYL)AMINO)CARBONYL)AZETIDINES | E.R. Squibb & Sons, Inc. (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4587047-A | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | disclosed |