Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 14/20 | 0.41 |
| ▸ | HTR2A | P28223 | 10/20 | 0.41 |
| ▸ | HTR2B | P41595 | 8/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28994087 | 0.84 | HTR2C (0.42) | HTR2CHTR2AHTR2BKCNH2 | |
| SCHEMBL21692939 | 0.70 | HTR2C (0.41) | HTR2CHTR2AHTR2BHTR5AADRB1 | |
| SCHEMBL20910802 | 0.70 | — | — | |
| SCHEMBL26178858 | 0.69 | HTR2C (0.41) | HTR2CHTR2AHTR2BNOTUMPNMT | |
| SCHEMBL13075669 | 0.69 | MAOA (0.40) | HTR1ADRD2DRD3 | |
| SCHEMBL7797306 | 0.69 | MEN1 (0.36) | HTR5AADRA2C | |
| SCHEMBL20912271 | 0.69 | ALDH1A1 (0.40) | HTR2AHTR1AHTR1DHTR7HTR5A | |
| SCHEMBL22791317 | 0.68 | HTR2C (0.42) | HTR2CHTR2AHTR2BHTR1AHTR5A | |
| SCHEMBL8986766 | 0.68 | BRD4 (0.34) | — | |
| SCHEMBL8986760 | 0.68 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198264-A2 | Carbamoyl imidazoles | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-10-22 | — | — | EP | disclosed |