Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHRH1SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC6A2
The experimentally established mechanism targets of Orphenadrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.54 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.54 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.54 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.54 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.54 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.54 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.54 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.40 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.40 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 8/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL29362028 | 0.92 | LMNA (0.62) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Orphenadrine SCHEMBL29369316 | 0.87 | KDM4E (1.00) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Orphenadrine SCHEMBL4451316 | 0.87 | KDM4E (1.00) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Orphenadrine SCHEMBL119470 | 0.87 | KDM4E (1.00) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Orphenadrine SCHEMBL10840687 | 0.84 | LMNA (0.75) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Orphenadrine SCHEMBL10840564 | 0.84 | LMNA (0.71) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Diphenhydramine SCHEMBL2948199 | 0.82 | LMNA (0.59) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Diphenhydramine SCHEMBL322306 | 0.78 | LMNA (0.80) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Diphenhydramine SCHEMBL7914760 | 0.77 | LMNA (0.79) | LMNAKDM4ECYP2D6CYP2C9CHRM1 | |
| Diphenhydramine SCHEMBL5678067 | 0.77 | LMNA (0.79) | LMNAKDM4ECYP2D6CYP2C9CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205492-A1 | ANALGESIC, ANTI-INFLAMMATORY AND SKELETAL MUSCLE RELAXANT COMPOSITIONS | SUNSHINE, Abraham (US) | 1986-12-30 | — | — | EP | disclosed |
| WO-1986003681-A1 | ANALGESIC, ANTI-INFLAMMATORY AND SKELETAL MUSCLE RELAXANT COMPOSITIONS | SUNSHINE ABRAHAM | 1986-07-03 | — | — | WO | disclosed |