Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842009 | 1.00 | BRAF (0.45) | BRAFALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10843461 | 0.85 | KDM4E (0.51) | BRAFALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL10842548 | 0.81 | BRAF (0.44) | BRAFCFTRSRPK1 | |
| SCHEMBL9728647 | 0.80 | KDM4E (0.48) | BRAFKDM4E | |
| SCHEMBL9878320 | 0.80 | KDM4E (0.48) | BRAFKDM4E | |
| SCHEMBL10842553 | 0.80 | HSD11B1 (0.38) | BRAFALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10842538 | 0.78 | BRAF (0.41) | BRAFHPGDHSD11B1CFTR | |
| SCHEMBL10842544 | 0.78 | BRAF (0.41) | BRAFHPGDHSD11B1CFTR | |
| SCHEMBL10842306 | 0.78 | KDM4E (0.49) | BRAFALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL9877207 | 0.73 | KDM4E (0.67) | BRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4576943-A | NERVOUS SYSTEM DISORDERS, SEDATIVES, HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-03-18 | — | — | US | claimed |