SCHEMBL10845366

SCHEMBL10845366

Cc1c(N)ccc(Cc2ccccc2)c1N

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.41
CALM1 P0DP23 1/20 0.41
BCL2 P10415 1/20 0.39
BCL2L1 Q07817 1/20 0.39
ALOX5 P09917 1/20 0.39
CYP3A4 P08684 2/20 0.38
TSHR P16473 2/20 0.38
PIK3CA P42336 1/20 0.38
USP2 O75604 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
RECQL P46063 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4650255 0.86 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1ALOX5
Water SCHEMBL9684780 0.85 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1ALOX5
Bromide SCHEMBL8174312 0.85 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1ALOX5
Iodide SCHEMBL22188505 0.85 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1ALOX5
Hydrochloric Acid SCHEMBL1559085 0.85 HTR2A (0.41) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL8063101 0.85 CYP3A4 (0.48) CYP3A4TSHRUSP2ALDH1A1CYP2D6
SCHEMBL8065484 0.83 CYP3A4 (0.42) CYP3A4TSHRPIK3CAALDH1A1MAPT
SCHEMBL31257130 0.82 CALM1 (0.46) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL10703986 0.81 PDCD1 (0.44) HTR2ABCL2BCL2L1ALOX5TSHR
Bicarbonate SCHEMBL22188527 0.80 ALDH1A1 (0.44) BCL2BCL2L1USP2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0173932-A2 Hair dyeing composition Henkel Kommanditgesellschaft auf Aktien (DE) 1986-03-12 EP disclosed