Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842976 | 0.79 | PDE3B (0.42) | PDE3BPDE3AAURKBINCENPCDC7 | |
| SCHEMBL10989508 | 0.76 | GAA (0.49) | PDE3BPDE3AAURKBINCENPCDC7 | |
| SCHEMBL10984156 | 0.76 | PDE3A (0.67) | PDE3BPDE3AAURKBINCENPCDC7 | |
| SCHEMBL10842595 | 0.76 | HSD17B1 (0.36) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL10980606 | 0.73 | ADORA2B (0.42) | PDE3BPDE3AAURKBINCENPCDC7 | |
| SCHEMBL10848672 | 0.72 | CCNT1 (0.42) | PDE3BPDE3AAURKBINCENPCDC7 | |
| SCHEMBL10847958 | 0.72 | GSK3B (0.36) | CDC7KDM4EHPGDTSHRCCNT1 | |
| SCHEMBL10842958 | 0.70 | KDM5A (0.33) | PDE3BPDE3ACDC7P2RX7MAPK14 | |
| SCHEMBL28205243 | 0.68 | CYP1A2 (0.53) | KDM4ETSHRCYP2C19P2RX7 | |
| SCHEMBL24968371 | 0.67 | HPGD (0.46) | KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4593028-A | 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure | WILLIAM H. RORER, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| US-4432979-A | Pyridone compounds | WILLIAM H. RORER, INC. (US) | 1984-02-21 | — | — | US | disclosed |