Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAPDH | P04406 | 1/20 | 0.35 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | MSN | P26038 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848193 | 1.00 | AKR1B1 (0.38) | AKR1B1ABCC9ABCB1MAPTGAPDH | |
| SCHEMBL10851967 | 0.82 | ABCC9 (0.39) | ABCC9KCNA5 | |
| SCHEMBL10851952 | 0.82 | ABCC9 (0.39) | ABCC9KCNA5 | |
| SCHEMBL10848198 | 0.81 | HTT (0.34) | AKR1B1ABCC9MAPTALDH1A1PKM | |
| SCHEMBL10847989 | 0.81 | ABCB1 (0.56) | ABCC9ABCB1 | |
| SCHEMBL10847997 | 0.81 | ABCB1 (0.56) | ABCC9ABCB1 | |
| SCHEMBL10846469 | 0.80 | AKR1B1 (0.36) | AKR1B1ABCC9GAPDHHSPA1AHSPA8 | |
| SCHEMBL10846477 | 0.80 | AKR1B1 (0.36) | AKR1B1ABCC9GAPDHHSPA1AHSPA8 | |
| SCHEMBL9398490 | 0.75 | ABCB1 (0.43) | ABCC9ABCB1 | |
| SCHEMBL9398532 | 0.75 | ABCB1 (0.43) | ABCC9ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4629734-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1986-12-16 | — | — | US | claimed |
| EP-0126350-A1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | claimed |
| US-4629734-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0126350-A1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | disclosed |