Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537564 | 0.81 | MAPT (0.79) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL14537571 | 0.77 | MAPT (0.76) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL14537568 | 0.77 | MAPT (0.72) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL10848812 | 0.77 | PDE4B (0.55) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL14537565 | 0.76 | MAPT (0.70) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL10565260 | 0.75 | KMT2A (0.51) | MAPTALDH1A1POLBL3MBTL1ATM | |
| SCHEMBL14537569 | 0.74 | MAPT (0.70) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL14537566 | 0.73 | MAPT (0.69) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL14537573 | 0.73 | MAPT (0.66) | MAPTALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL27728269 | 0.73 | MAPT (0.77) | MAPTALDH1A1POLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |