Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848760 | 0.90 | MAPT (0.50) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL10738294 | 0.85 | MAPT (0.43) | ALDH1A1KDM4ESMN1; SMN2RXFP1MAPT | |
| SCHEMBL10742091 | 0.83 | MEN1 (0.43) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL11244977 | 0.81 | ALDH1A1 (0.78) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| Hydrochloric Acid SCHEMBL11254237 | 0.80 | ALDH1A1 (0.80) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL10566652 | 0.78 | PDE4B (0.54) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL10848778 | 0.77 | MAPT (0.63) | ALDH1A1KDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL10846042 | 0.77 | PDE4B (0.51) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL10509852 | 0.77 | MEN1 (0.44) | PDE4BALDH1A1KDM4ESMN1; SMN2RXFP1 | |
| SCHEMBL11765789 | 0.77 | NPC1 (0.72) | PDE4BALDH1A1SMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |