Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.31 |
| ▸ | GABRE | P78334 | 2/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.31 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3199100 | 0.88 | FFAR3 (0.39) | THRBOR51E2GABRPGABRDGABRA1 | |
| Acetic Acid SCHEMBL11514850 | 0.88 | FFAR3 (0.39) | THRBOR51E2GABRPGABRDGABRA1 | |
| Acetic Acid SCHEMBL23907964 | 0.88 | FFAR3 (0.39) | THRBOR51E2GABRPGABRDGABRA1 | |
| Carbamic Acid SCHEMBL28125700 | 0.88 | ACHE (0.39) | THRBOR51E2GABRPGABRDGABRA1 | |
| SCHEMBL15315 | 0.87 | — | — | |
| Urea SCHEMBL27982677 | 0.85 | THRB (0.36) | THRBOR51E2ALDH1A1LMNA | |
| Thioglycolic Acid SCHEMBL27952646 | 0.84 | GSTK1 (0.35) | THRBOR51E2GABRPGABRDGABRA1 | |
| Water SCHEMBL1781387 | 0.83 | — | — | |
| SCHEMBL28564382 | 0.83 | — | — | |
| SCHEMBL28548666 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116034146-A | Polyol compounds and adhesive compositions prepared therewith | 陶氏环球技术有限责任公司 | 2023-04-28 | — | — | CN | claimed |
| CN-116034146-A | Polyol compounds and adhesive compositions prepared therewith | 陶氏环球技术有限责任公司 | 2023-04-28 | — | — | CN | disclosed |
| US-4568755-A | COPOLYMER PRECURSORS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-02-04 | — | — | US | disclosed |