Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 6/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10689222 | 0.90 | KDM4E (0.43) | SCDAMY1APDE5APDE3BPDE3A | |
| SCHEMBL10685898 | 0.88 | MAPT (0.46) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL10970632 | 0.84 | PDE2A (0.45) | CDK4CCND1AMY1APDE5APDE3B | |
| SCHEMBL9703335 | 0.83 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL9702805 | 0.82 | CDK4 (0.45) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL9702854 | 0.81 | CDK4 (0.45) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL10852513 | 0.81 | AMY1A (0.40) | AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10849719 | 0.81 | AMY1A (0.41) | AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10677421 | 0.80 | PDE5A (0.50) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL9704494 | 0.79 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568680-A | LOWERRS BLOOD PRESSURE, HYPOTENSIVE ACTIVITY | DR. KARL THOMAE GMBH (DE) | 1986-02-04 | — | — | US | disclosed |
| EP-0149131-A2 | Imidazo (4,5-c) pyridinones, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |