Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HTR5A | P47898 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10851703 | 0.86 | ABCB1 (0.41) | KDM4EHSD17B10HTR5AALDH1A1HPGD | |
| SCHEMBL10854607 | 0.84 | ABCB1 (0.39) | KDM4EHSD17B10HTR5AALDH1A1HPGD | |
| SCHEMBL10851137 | 0.84 | HTR5A (0.40) | KMT2AKDM4EHSD17B10HTR5AALDH1A1 | |
| SCHEMBL11112201 | 0.83 | HTR5A (0.39) | KMT2AKDM4EHTR5AMAPTABCB1 | |
| SCHEMBL11112533 | 0.83 | HTR1A (0.54) | HTR7KMT2AKDM4EHTR5AALDH1A1 | |
| SCHEMBL11113912 | 0.82 | EGFR (0.41) | TSHRKMT2AKDM4EHSD17B10HTR5A | |
| SCHEMBL11112920 | 0.82 | ABCB1 (0.40) | KMT2AKDM4EHSD17B10HTR5AHPGD | |
| SCHEMBL10853849 | 0.82 | ABCB1 (0.38) | HTR5AABCB1ABCG2 | |
| SCHEMBL10804195 | 0.82 | ABCB1 (0.38) | KDM4EHTR5AMAPTABCB1ABCG2 | |
| SCHEMBL10804503 | 0.82 | ABCB1 (0.40) | TSHRKDM4EHSD17B10HTR5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |
| EP-0101574-A1 | 2-Substituted 1-aminoalkyl-1,2,3,4-tetrahydro-beta-carbolines, their preparation and use as medicaments | BASF Aktiengesellschaft (DE) | 1984-02-29 | — | — | EP | disclosed |