Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL27724093 | 0.97 | CES2 (0.41) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL669342 | 0.97 | CES2 (0.41) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL9792320 | 0.92 | ALDH1A1 (0.38) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL974340 | 0.88 | CES2 (0.43) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclooctanamine SCHEMBL11193013 | 0.88 | CES2 (0.43) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL578785 | 0.88 | CES2 (0.43) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cycloheptanamine SCHEMBL720218 | 0.88 | CES2 (0.43) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL974731 | 0.86 | EPHX1 (0.44) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL11585174 | 0.86 | EPHX1 (0.44) | ALDH1A1CES2CES1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL28119655 | 0.86 | EPHX1 (0.44) | ALDH1A1CES2CES1MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584316-A | ANTITUMOR AGENTS | RESEARCH CORPORATION (US) | 1986-04-22 | — | — | US | disclosed |