Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL27724093 | 1.00 | CES2 (0.41) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL10857134 | 0.97 | ALDH1A1 (0.39) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL9792320 | 0.95 | ALDH1A1 (0.38) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL578785 | 0.91 | CES2 (0.43) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cycloheptanamine SCHEMBL720218 | 0.91 | CES2 (0.43) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL974340 | 0.91 | CES2 (0.43) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclooctanamine SCHEMBL11193013 | 0.91 | CES2 (0.43) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL11585174 | 0.88 | EPHX1 (0.44) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL974731 | 0.88 | EPHX1 (0.44) | CES2CES1ALDH1A1MMP8MMP1 | |
| Cyclohexylamine SCHEMBL28119655 | 0.88 | EPHX1 (0.44) | CES2CES1ALDH1A1MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106715557-A | Monobenzoate analogs useful as plasticizers in plastisol compositions | 艾默罗德卡拉玛化学品公司 | 2017-05-24 | — | — | CN | disclosed |
| EP-2605772-B1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNAT AG (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-20150259284-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNATIONAL SA (CH) | 2015-09-17 | — | — | US | disclosed |
| US-9006460-B2 | Process for preparing aminocyclohexyl ether compounds | CARDIOME INTERNATIONAL AG (CH) | 2015-04-14 | — | — | US | disclosed |
| EP-2605772-A2 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130149751-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNATIONAL SA (CH) | 2013-06-13 | — | — | US | disclosed |
| WO-2012024100-A2 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| CN-101245019-B | Novel technique for synthesizing quaternary ammonium salt | QIU JIANXING | 2011-04-20 | — | — | CN | disclosed |
| CN-101245019-A | Novel technique for synthesizing quaternary ammonium salt | QIU JIANXING (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101014570-A | Piperidine derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2007-08-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259284-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP3A43, CYP4B1, CYP3A4 | CES2 363/4885CES1 289/4885ALDH1A1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.