Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11441247 | 0.77 | MEN1 (0.50) | ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15 | |
| SCHEMBL10999263 | 0.72 | ALDH1A1 (0.48) | ALDH1A1CYP3A4ALOX15TDP1LMNA | |
| 1,4-Dichlorobenzene SCHEMBL29138720 | 0.67 | LMNA (0.80) | ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15 | |
| SCHEMBL11106606 | 0.67 | MAPT (0.50) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL10999656 | 0.67 | TDP1 (0.54) | ALDH1A1CYP3A4SMN1; SMN2TDP1CYP2A6 | |
| SCHEMBL11193755 | 0.67 | TYR (0.56) | ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15 | |
| 1,4-Dichlorobenzene SCHEMBL11243685 | 0.67 | — | — | |
| 1,4-Dichlorobenzene SCHEMBL5191 | 0.67 | — | — | |
| 4-Chloroaniline SCHEMBL27475886 | 0.65 | MAOA (0.68) | ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15 | |
| 4-Chloroaniline SCHEMBL16922177 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563453-A | ANTIINFLAMMATORY, ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-07 | — | — | US | disclosed |
| US-4540692-A | Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-09-10 | — | — | US | disclosed |
| EP-0138223-A2 | Thiazine derivatives, processes for preparation thereof and pharmaceutical conmposition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-04-24 | — | — | EP | disclosed |
| EP-0126894-A1 | Tropone derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-12-05 | — | — | EP | disclosed |
| US-4381304-A | 4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives | AYERST, MCKENNA & HARRISON, INC. (CA) | 1983-04-26 | — | — | US | disclosed |
| US-4337265-A | COMPLICATIONS OF DIABETES | AYERST, MCKENNA & HARRISON INC. (CA) | 1982-06-29 | — | — | US | disclosed |