Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855358 | 0.85 | TBXAS1 (0.67) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| SCHEMBL10854889 | 0.81 | TBXAS1 (0.64) | TBXAS1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10855281 | 0.81 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL149467 | 0.73 | TBXAS1 (1.00) | TBXAS1 | |
| Hydrochloric Acid SCHEMBL10853833 | 0.72 | TBXAS1 (0.98) | TBXAS1 | |
| SCHEMBL10858277 | 0.71 | TBXAS1 (0.36) | TBXAS1 | |
| SCHEMBL10859530 | 0.71 | TBXAS1 (0.33) | TBXAS1 | |
| SCHEMBL10853070 | 0.71 | CYP19A1 (0.72) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| SCHEMBL2798439 | 0.71 | CYP11B1 (0.62) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| SCHEMBL10859489 | 0.70 | TBXAS1 (0.77) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |