Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10858078 | 0.85 | TBXAS1 (0.67) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| SCHEMBL10860344 | 0.81 | TBXAS1 (0.64) | TBXAS1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10861539 | 0.81 | TBXAS1 (1.00) | TBXAS1CYP19A1 | |
| SCHEMBL10584615 | 0.73 | ASIC3 (0.41) | TBXAS1KDM4EALDH1A1LMNACYP2A6 | |
| SCHEMBL10855114 | 0.71 | ASIC3 (0.40) | TBXAS1KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL10853495 | 0.71 | TBXAS1 (0.78) | TBXAS1CYP19A1KDM4EMAPK1 | |
| SCHEMBL11217390 | 0.70 | ASIC3 (0.39) | TBXAS1 | |
| SCHEMBL707075 | 0.69 | CYP11B1 (1.00) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| Hydrochloric Acid SCHEMBL10465963 | 0.68 | CYP11B1 (0.49) | TBXAS1CYP11B1CYP11B2CYP19A1ADRA2C | |
| SCHEMBL10854889 | 0.67 | TBXAS1 (0.64) | TBXAS1CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |