Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11362783 | 0.86 | ALDH1A1 (0.33) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL10858680 | 0.85 | MAPT (0.38) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL11362104 | 0.83 | CYP3A4 (0.37) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL11367818 | 0.82 | ALDH1A1 (0.34) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| Sulfuric Acid SCHEMBL11371102 | 0.78 | ALOX15 (0.38) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL11315121 | 0.78 | IDO1 (0.34) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL10861848 | 0.75 | ATM (0.33) | ALDH1A1LMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL11310096 | 0.75 | ACHE (0.40) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL11819562 | 0.75 | MAPT (0.40) | ALDH1A1LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL10859951 | 0.75 | ALDH1A1 (0.33) | ALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578388-A | HISTAMINE H2-ANTAGONIST; ANTISECRETORY AGENTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4405621-A | Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-09-20 | — | — | US | disclosed |
| US-4301165-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-11-17 | — | — | US | disclosed |
| US-4197305-A | Thiazole, isothiazole, oxazole and isoxazole compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-04-08 | — | — | US | disclosed |
| US-4151289-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137319-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4133886-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-09 | — | — | US | disclosed |