Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683878 | 0.89 | LMNA (0.80) | LMNASMN1; SMN2POLBADORA2BMEN1 | |
| (S)-Proxyphylline SCHEMBL35570 | 0.89 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMEN1 | |
| Proxyphylline SCHEMBL35569 | 0.89 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMEN1 | |
| SCHEMBL13944619 | 0.87 | LMNA (0.81) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| SCHEMBL11611771 | 0.86 | LMNA (0.60) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Isbufylline SCHEMBL678978 | 0.85 | LMNA (0.78) | LMNASMN1; SMN2POLBADORA2BMEN1 | |
| SCHEMBL11830512 | 0.84 | LMNA (0.77) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| SCHEMBL20161775 | 0.84 | LMNA (0.77) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| SCHEMBL17486883 | 0.84 | LMNA (0.76) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Dyphylline SCHEMBL123781 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4576947-A | HYDROXYALKYLXANTHINES, INCREASING CEREBRAL BLOOD FLOW, BRONCHODILATORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-03-18 | — | — | US | disclosed |
| US-4515795-A | INSUFFICIENCY OF CEREBRAL BLOOD FLOW | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-05-07 | — | — | US | disclosed |