Proxyphylline

Proxyphylline

SCHEMBL35569

CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
POLB P06746 2/20 0.75
ADORA2B P29275 9/20 0.67
MAPT P10636 1/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
RXFP1 Q9HBX9 2/20 0.60
GAA P10253 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(S)-Proxyphylline SCHEMBL35570 1.00 LMNA (1.00) LMNASMN1; SMN2POLBADORA2BMAPT
Dyphylline SCHEMBL13724353 0.92 LMNA (0.90) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL13944619 0.90 LMNA (0.81) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL683878 0.89 LMNA (0.80) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL10859640 0.89 LMNA (0.80) LMNASMN1; SMN2POLBADORA2BMAPT
Isbufylline SCHEMBL678978 0.88 LMNA (0.78) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL20161775 0.87 LMNA (0.77) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL11830512 0.87 LMNA (0.77) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL11123833 0.86 LMNA (0.75) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL17486883 0.86 LMNA (0.76) LMNASMN1; SMN2POLBADORA2BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 28952 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250017878-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY CHRONIC AIRWAY THERAPEUTICS LTD (AU) 2025-01-16 US claimed
US-20250006331-A1 QUANTITATIVE SYSTEMS PHARMACOLOGY METHODS FOR IDENTIFYING THERAPEUTICS FOR DISEASE STATES UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) 2025-01-02 US claimed
WO-2024189434-A1 USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2024-09-19 WO claimed
WO-2024141752-A1 MAGNETICALLY GEARED SYSTEMS AND METHODS MAGNOMATICS LIMITED (GB) 2024-07-04 WO claimed
CN-117919253-A Application of xanthine compound in preparation of medicines for activating primordial follicles 华南理工大学 2024-04-26 CN claimed
US-11966042-B2 Augmented reality display units and augmented reality headsets comprising the same ADLENS LTD. (GB) 2024-04-23 US claimed
CN-117691920-B Automatic control method for servo motor 成都航空职业技术学院 2024-04-12 CN claimed
CN-112288679-B Interactive extraction method and system for defect area of automobile hub X-ray image 中北大学 2024-03-29 CN claimed
CN-117531218-A Pressure reduction control device for improving carbon dioxide yield 山西潞安煤基合成油有限公司 2024-02-09 CN claimed
EP-4304717-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY Chronic Airway Therapeutics Limited (AU) 2024-01-17 EP claimed
EP-0213083-A2 Controlled release tablet Zyma SA (CH) 1987-03-04 EP claimed
EP-0193599-A1 XANTHINE DERIVATIVE PEST CONTROL AGENTS THE GENERAL HOSPITAL CORPORATION (US) 1986-09-10 EP claimed
US-4581359-A FOR BRONCHOPULMONARY INSUFFUCIENCY THE STATE OF OREGON ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) 1986-04-08 US claimed
WO-1986001724-A1 XANTHINE DERIVATIVE PEST CONTROL AGENTS THE GENERAL HOSPITAL CORPORATION (US) 1986-03-27 WO claimed
US-4499170-A Lithographic plates and photoresists having stabilized photosensitive diazo resin with theophylline derivative RICHARDSON GRAPHICS COMPANY (US) 1985-02-12 US claimed
US-4425345-A XANTHINE SOLUBILIZER SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) 1984-01-10 US claimed
US-4425346-A ANTIGLAUCOMA AGENTS SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) 1984-01-10 US claimed
EP-0045617-A2 Pharmaceutical composition Smith and Nephew Associated Companies p.l.c. (GB) 1982-02-10 EP claimed
US-4117132-A PROCESS FOR THE PRODUCTION OF STABILIZED PURE THEOPHYLLINE IN NEUTRAL, AQUEOUS SOLUTION DR. ADOLF SEEBACH AG (CH) 1978-09-26 US claimed
US-3986852-A ROTARY COOLING AND HEATING APPARATUS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-10-19 US claimed