(S)-Proxyphylline

(S)-Proxyphylline

SCHEMBL35570

C[C@H](O)Cn1cnc2c1c(=O)n(C)c(=O)n2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
POLB P06746 2/20 0.75
ADORA2B P29275 9/20 0.67
MAPT P10636 1/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
RXFP1 Q9HBX9 2/20 0.60
GAA P10253 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proxyphylline SCHEMBL35569 1.00 LMNA (1.00) LMNASMN1; SMN2POLBADORA2BMAPT
Dyphylline SCHEMBL13724353 0.92 LMNA (0.90) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL13944619 0.90 LMNA (0.81) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL683878 0.89 LMNA (0.80) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL10859640 0.89 LMNA (0.80) LMNASMN1; SMN2POLBADORA2BMAPT
Isbufylline SCHEMBL678978 0.88 LMNA (0.78) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL20161775 0.87 LMNA (0.77) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL11830512 0.87 LMNA (0.77) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL11123833 0.86 LMNA (0.75) LMNASMN1; SMN2POLBADORA2BMAPT
SCHEMBL17486883 0.86 LMNA (0.76) LMNASMN1; SMN2POLBADORA2BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 26737 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024141752-A1 MAGNETICALLY GEARED SYSTEMS AND METHODS MAGNOMATICS LIMITED (GB) 2024-07-04 WO claimed
CN-117191497-A Online analysis pretreatment system for raw gas of BGL gasifier 眉山麦克在线设备股份有限公司 2023-12-08 CN claimed
US-11832265-B2 Method and apparatus for indicating slot format in wireless communication system SAMSUNG ELECTRONICS CO., LTD 2023-11-28 US claimed
US-20230275206-A1 APPARATUS FOR MANUFACTURING POSITIVE ELECTRODE FILM, MANUFACTURING METHOD USING SAME, AND POSITIVE ELECTRODE FILM MANUFACTURED USING SAME LG ENERGY SOLUTION, LTD. (KR) 2023-08-31 US claimed
US-11733502-B2 Spatial posture adjusting device for optical axis of microscopic monitoring system for cellular fermentation tank CHANGCHUN UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2023-08-22 US claimed
US-20230219663-A1 SYSTEM AND METHOD FOR FUMIGATING A VESSEL WITH CREW PROTECTION Fintran Australia Pty Ltd (AU) 2023-07-13 US claimed
US-11691177-B2 Ultrasound probe with acoustic amplifier ESAOTE S.P.A. (IT) 2023-07-04 US claimed
US-11684697-B2 Tissue-engineered medical device Universität Zürich (CH) 2023-06-27 US claimed
US-11525288-B2 Motor vehicle locking system with an electrical opening device KIEKERT AG (DE) 2022-12-13 US claimed
US-11257082-B2 Payment system and method MICROSOFT TECHNOLOGY LICENSING, LLC (US) 2022-02-22 US claimed
US-6723611-B2 Vertical hard mask INTERNATIONAL BUSINESS MACHINES CORPORATION 2004-04-20 US claimed
US-RE38413-E1 Pure red color detection circuit and color compensation circuit using the same MATSUSHITA ELECTRIC INDUSTRIAL CO. LTD. (JP) 2004-02-03 US claimed
US-RE38211-E1 Uni-directional cord take-up device RETRACTABLE CORD TECHNOLOGIES LLC 2003-08-12 US claimed
US-RE38078-E1 Graphical rendering system using simultaneous parallel query Z-buffer and method therefor APPLE COMPUTER, INC. 2003-04-15 US claimed
US-RE38062-E1 Microwave and millimeter wave stripline filter and process for fabricating same STRATEDGE CORPORATION 2003-04-08 US claimed
WO-2003020219-A2 AEROSOLIZED DECONGESTANTS FOR THE TREATMENT OF SINUSITIS SINUSPHARMA INC (US) 2003-03-13 WO claimed
US-RE37737-E1 Automobile windshield molding and method of producing the same TOKAI KOGYO KABUSHIKI KAISHA (JP) 2002-06-11 US claimed
US-RE37261-E1 Axially compact small fan PAPST LICENSING GMBH & CO. KG (DE) 2001-07-03 US claimed
EP-0211283-B1 FOOTWEAR AUTOMATICALLY PERFORMING A MASSAGE DURING THE WALK De Taddeo, Giancarlo (IT) 1990-10-24 EP claimed
US-3986852-A ROTARY COOLING AND HEATING APPARATUS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-10-19 US claimed