Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.55 |
| ▸ | USP2 | O75604 | 6/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258709 | 0.87 | LMNA (0.46) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL1086439 | 0.85 | MAPK1 (0.48) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL1086354 | 0.81 | SIRT2 (0.42) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL1086353 | 0.81 | SIRT2 (0.45) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL4266724 | 0.79 | LMNA (0.40) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL1086171 | 0.78 | CYP3A4 (0.45) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL4260720 | 0.78 | MEN1 (0.46) | FAAHCYP3A4ALDH1A1CYP2C19USP2 | |
| SCHEMBL1085842 | 0.77 | CYP2D6 (0.48) | CYP3A4ALDH1A1CYP2C19USP2MAPK1 | |
| SCHEMBL1086699 | 0.77 | SIRT2 (0.41) | FAAHALDH1A1CYP2C19MAPK1CYP1A2 | |
| SCHEMBL1085855 | 0.77 | RIPK1 (0.49) | CYP3A4ALDH1A1CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153795-B2 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs | GRUENENTHAL GMBH (DE) | 2012-04-10 | — | — | US | disclosed |
| US-8153795-B2 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs | GRUENENTHAL GMBH (DE) | 2012-04-10 | — | — | US | disclosed |
| US-8153795-B2 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs | GRUENENTHAL GMBH (DE) | 2012-04-10 | — | — | US | disclosed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20090105290-A1 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs | GRUENENTHAL GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105290-A1 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs | GRUENENTHAL GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105290-A1 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs | DDO, DAO, OTC | FAAH 2616/4885CYP3A4 60/4885ALDH1A1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.