Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266724 | 0.85 | LMNA (0.40) | KMT2ALMNAUSP2CYP2C19CYP1A2 | |
| SCHEMBL1086354 | 0.81 | SIRT2 (0.42) | USP2CYP2C19CYP1A2CYP3A4TACR1 | |
| SCHEMBL1086185 | 0.80 | MEN1 (0.45) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL1086102 | 0.78 | FAAH (0.56) | USP2CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1086591 | 0.77 | GRM2 (0.44) | KMT2ATSHRFAAH | |
| SCHEMBL1086353 | 0.77 | SIRT2 (0.45) | USP2CYP2C19CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1086439 | 0.76 | MAPK1 (0.48) | USP2CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1086171 | 0.75 | CYP3A4 (0.45) | MEN1KMT2AUSP2CYP2C19CYP1A2 | |
| SCHEMBL1085948 | 0.74 | POLB (0.46) | MEN1KMT2ALMNAPOLBKDM4E | |
| SCHEMBL1086699 | 0.74 | SIRT2 (0.41) | CYP2C19CYP1A2TSHRTACR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |