Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63455 | 0.82 | CHRM2 (0.40) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL6129709 | 0.82 | CHRM2 (0.40) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| Terephthalic Acid SCHEMBL8518419 | 0.80 | TSHR (0.36) | TDP1TRPA1ALDH1A1 | |
| Terephthalic Acid SCHEMBL7901428 | 0.73 | TSHR (0.46) | TRPA1ALDH1A1 | |
| Biphenyl SCHEMBL25224475 | 0.69 | TDP1 (0.53) | TDP1TRPA1LMNAPTGS2ALDH1A1 | |
| Benzene SCHEMBL2865297 | 0.68 | TDP1 (0.77) | TDP1TRPA1LMNAALDH1A1KDM4E | |
| Phenol SCHEMBL5694604 | 0.68 | TDP1 (0.55) | TDP1TRPA1LMNAALDH1A1KDM4E | |
| Phenol SCHEMBL2703945 | 0.68 | TDP1 (0.55) | TDP1TRPA1LMNAALDH1A1KDM4E | |
| Toluene SCHEMBL11299292 | 0.68 | LMNA (0.55) | TDP1TRPA1LMNAALDH1A1KDM4E | |
| Phenol SCHEMBL28075164 | 0.68 | TDP1 (0.55) | TDP1TRPA1LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61243825-A | — | — | None | — | — | JP | disclosed |
| JP-S61243825-A | PRODUCTION OF AIR-DRYING UNSATURATED POLYESTER RESIN | NIPPON SYNTHETIC CHEM IND CO LTD:THE | 1986-10-30 | — | — | JP | disclosed |