Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL8518419 | 0.88 | TSHR (0.36) | TSHRDAONAPRTSRD5A2CES2 | |
| SCHEMBL6129709 | 0.84 | CHRM2 (0.40) | — | |
| SCHEMBL63455 | 0.84 | CHRM2 (0.40) | — | |
| Terephthalic Acid SCHEMBL31606966 | 0.78 | TSHR (0.55) | TSHRDAONAPRTSRD5A2CES2 | |
| Propylene Glycol SCHEMBL10865600 | 0.73 | TDP1 (0.36) | ALDH1A1TRPA1 | |
| Terephthalic Acid SCHEMBL27810731 | 0.71 | TSHR (0.57) | TSHRDAONAPRTSRD5A2CES2 | |
| SCHEMBL329170 | 0.71 | AKR1C1 (0.39) | ALOX15ALDH1A1 | |
| Terephthalic Acid SCHEMBL7526066 | 0.70 | TSHR (0.72) | TSHRDAONAPRTSRD5A2CES2 | |
| Benzoic Acid SCHEMBL28173856 | 0.70 | TSHR (0.82) | TSHRDAONAPRTSRD5A2CES2 | |
| Benzoic Acid SCHEMBL2806428 | 0.70 | TSHR (0.64) | TSHRDAONAPRTSRD5A2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187489-B1 | FLUIDITY, CHARGING, DEVELOPING, AND TRANSFERRING PROPERTY, PREVENTS FORMATION OF FOG ON PHOTOSENSITIVE MATERIAL AND STAINING OF INSIDE OF COPYING MACHINE | FUJI XEROX CO., LTD (JP) | 2001-02-13 | — | — | US | disclosed |
| US-5891600-A | TONER, BINDER RESIN AND COLOR AND ADDITIVE WITH TITANIUM OXYHYDROXIDE REACTED WITH SILANE AND SILICON OIL | FUJI XEROX CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |