SCHEMBL6129709

SCHEMBL6129709

C[C@@H]1OC1(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.40
CHRM4 P08173 3/20 0.40
CHRM1 P11229 3/20 0.40
CHRM3 P20309 3/20 0.40
CHRM5 P08912 2/20 0.40
SIGMAR1 Q99720 1/20 0.39
OPRL1 P41146 2/20 0.36
CHRNB2 P17787 1/20 0.36
SLC6A2 P23975 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
SLC6A3 Q01959 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRK1 P41145 1/20 0.36
MAOB P27338 4/20 0.34
MAOA P21397 3/20 0.34
CYP3A4 P08684 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL63455 1.00 CHRM2 (0.40) CHRM2CHRM4CHRM1CHRM3CHRM5
Terephthalic Acid SCHEMBL7901428 0.84 TSHR (0.46)
Propylene Glycol SCHEMBL10865600 0.82 TDP1 (0.36) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL3471203 0.78 CHRM2 (0.36) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL2763761 0.77 CHRNB2 (0.39) OPRL1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL28366383 0.77 CHRNB2 (0.39) OPRL1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL2763759 0.77 CHRNB2 (0.39) OPRL1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL10362472 0.77 SLC6A3 (0.41) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL3971547 0.75 CHRM2 (0.49) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL7108506 0.75 CHRM2 (0.49) CHRM2CHRM4CHRM1CHRM3CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1154764-A4 EPOXIDE HYDROLASE COMPLEXES AND METHODS THEREWITH UNIV CALIFORNIA (US) 2005-02-16 EP disclosed
EP-1154764-A1 EPOXIDE HYDROLASE COMPLEXES AND METHODS THEREWITH THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-11-21 EP disclosed
WO-2000048593-A1 EPOXIDE HYDROLASE COMPLEXES AND METHODS THEREWITH THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-08-24 WO disclosed