SCHEMBL10870243

SCHEMBL10870243

CC(C)(C)c1cc(Nc2nc(Cl)nc(Cl)n2)cc(C(C)(C)C)c1O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 4/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
NPC1 O15118 2/20 0.43
RAB9A P51151 1/20 0.43
CA2 P00918 3/20 0.42
CA1 P00915 2/20 0.42
POLB P06746 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TYR P14679 1/20 0.41
MAPT P10636 4/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPK1 P28482 1/20 0.41
KDM4E B2RXH2 1/20 0.40
TXN P10599 1/20 0.39
LMNA P02545 1/20 0.39
HPN P05981 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10869800 0.97 NPC1 (0.46) NFKB1ALDH1A1GAATDP1NPC1
SCHEMBL11537458 0.91 CYP1A2 (0.45) NFKB1ALDH1A1GAATDP1NPC1
SCHEMBL9723791 0.90 HSP90AA1 (0.40) NFKB1ALDH1A1GAATDP1NPC1
SCHEMBL11537650 0.88 CYP1A2 (0.45) NFKB1ALDH1A1GAATDP1NPC1
SCHEMBL11613891 0.80 ALDH1A1 (0.45) NFKB1ALDH1A1GAATDP1CA2
SCHEMBL10870867 0.78 PTGS1 (0.34) NPC1RAB9ASMN1; SMN2MAPTMEN1
SCHEMBL6131350 0.78 ALDH1A1 (0.46) NFKB1ALDH1A1GAATDP1CA2
SCHEMBL18459329 0.78 CA2 (0.61) NFKB1ALDH1A1GAATDP1CA2
SCHEMBL11307641 0.78 GSR (0.50) NFKB1ALDH1A1GAATDP1CA2
SCHEMBL5968134 0.78 ALDH1A1 (0.42) NFKB1ALDH1A1GAATDP1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111825628-A Synthetic method of antioxidant 565 湖北华恒达化工有限公司 2020-10-27 CN claimed
CN-111393381-B Phenolic amine compound and preparation method and application thereof 玛可索(苏州)石化有限公司 2021-10-01 CN disclosed
CN-111825628-A Synthetic method of antioxidant 565 湖北华恒达化工有限公司 2020-10-27 CN disclosed
CN-111393381-A Phenolic amine compound and preparation method and application thereof 玛可索(苏州)石化有限公司 2020-07-10 CN disclosed
EP-0185989-A2 Thermal oxidation-protected compositions of polymers containing hydroxyl or amino groups, their production and use BASF Aktiengesellschaft (DE) 1986-07-02 EP disclosed
US-4297492-A STABILIZERS FOR PLASTICS CIBA-GEIGY CORPORATION (US) 1981-10-27 US disclosed