Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873080 | 1.00 | GAA (0.43) | GAATSHRKLKB1PSMB5PSMB1 | |
| SCHEMBL10872890 | 0.88 | TSHR (0.44) | TSHRPSMB5PSMB1MAPTPOLB | |
| SCHEMBL10872887 | 0.88 | TSHR (0.44) | TSHRPSMB5PSMB1MAPTPOLB | |
| SCHEMBL10872615 | 0.85 | L3MBTL1 (0.47) | TSHRPSMB5MAPTPOLBKDM4E | |
| SCHEMBL10872610 | 0.85 | L3MBTL1 (0.47) | TSHRPSMB5MAPTPOLBKDM4E | |
| SCHEMBL10873376 | 0.85 | SMN1; SMN2 (0.49) | GAATSHRPSMB5POLBKDM4E | |
| SCHEMBL10875306 | 0.81 | CES1 (0.41) | GAAMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10872044 | 0.80 | TSHR (0.54) | GAATSHRMAPTNPC1RAB9A | |
| SCHEMBL10873225 | 0.77 | TSHR (0.39) | GAATSHRPSMB5PSMB1MAPT | |
| SCHEMBL10873229 | 0.77 | TSHR (0.39) | GAATSHRPSMB5PSMB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0194484-A2 | Synthesis of 1-(2-amino-2-phenylethyl)-2-piperidinones | PENNWALT CORPORATION (US) | 1986-09-17 | — | — | EP | disclosed |