Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.56 |
| ▸ | AR | P10275 | 11/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.56 |
| ▸ | SHBG | P04278 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843682 | 0.84 | PGR (0.78) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL11858281 | 0.84 | PGR (0.78) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL10873501 | 0.84 | PGR (0.49) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL10872314 | 0.83 | PGR (0.44) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL11044513 | 0.80 | PGR (0.56) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL11317752 | 0.80 | PGR (0.80) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL10873247 | 0.80 | LMNA (0.47) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL10596154 | 0.79 | PGR (0.54) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL11862865 | 0.79 | PGR (0.66) | PGRARNR3C1LMNACYP3A4 | |
| SCHEMBL20851736 | 0.79 | PGR (0.72) | PGRARNR3C1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092173-B1 | 11-BETA-CHLOROSTEROIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-03-05 | — | — | EP | claimed |