Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 3/20 | 0.31 |
| ▸ | CELA1 | Q9UNI1 | 2/20 | 0.31 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TPMT | P51580 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4317657 | 0.84 | POLB (0.56) | POLBNLRP3TTRKDM4EHSD17B10 | |
| SCHEMBL18290075 | 0.77 | POLB (0.48) | POLBNLRP3TTRABCB11KDM4E | |
| SCHEMBL10874720 | 0.76 | POLB (0.48) | POLBNLRP3TTRABCB11KDM4E | |
| SCHEMBL10874728 | 0.75 | POLB (0.47) | POLBNLRP3TTRABCB11KDM4E | |
| Clioxanide SCHEMBL29358452 | 0.74 | POLB (1.00) | POLBNLRP3ALDH1A1TOP1HTT | |
| Clioxanide SCHEMBL636665 | 0.74 | POLB (1.00) | POLBNLRP3ALDH1A1TOP1HTT | |
| SCHEMBL18290079 | 0.74 | POLB (0.46) | POLBNLRP3TTRKDM4EHSD17B10 | |
| SCHEMBL20413309 | 0.72 | POLB (0.79) | POLBNLRP3KDM4EHSD17B10TOP1 | |
| SCHEMBL14223805 | 0.72 | POLB (0.72) | POLBNLRP3ABCB11KDM4EALDH1A1 | |
| SCHEMBL26176577 | 0.72 | POLB (0.76) | POLBNLRP3ALDH1A1HPGDTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150719-B1 | SUBSTITUTED SALICYLAMIDES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | BAYER AG (DE) | 1986-10-15 | — | — | EP | disclosed |
| US-4565888-A | Substituted salicylic acid amide anthelmintics | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-21 | — | — | US | disclosed |
| EP-0150719-A1 | Substituted salicylamides, process for their production and their use as pharmaceutical preparations | BAYER AG (DE) | 1985-08-07 | — | — | EP | disclosed |