Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11107670 | 0.90 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2HTTNPC1 | |
| E1501 SCHEMBL14031569 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| E1501 SCHEMBL901210 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| E1501 SCHEMBL28201296 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| E1501 SCHEMBL43745 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3487087 | 0.85 | LMNA (0.61) | ALDH1A1LMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL11085496 | 0.84 | LMNA (0.74) | ALDH1A1LMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL25848262 | 0.84 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HTTL3MBTL1 | |
| E1501 SCHEMBL18954294 | 0.84 | ALDH1A1 (0.96) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| E1501 SCHEMBL183528 | 0.84 | ALDH1A1 (0.96) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128718-B1 | PROCESS FOR 6-(AMINOMETHYL)PENICILLANIC ACID 1,1-DIOXIDE AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1986-12-30 | — | — | EP | claimed |
| US-4502990-A | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof | PFIZER INC. (US) | 1985-03-05 | — | — | US | claimed |
| EP-0128718-A1 | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof | PFIZER INC. (US) | 1984-12-19 | — | — | EP | claimed |
| EP-0128718-B1 | PROCESS FOR 6-(AMINOMETHYL)PENICILLANIC ACID 1,1-DIOXIDE AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0128719-B1 | 6-(AMINOMETHYL)PENICILLANIC ACID 1,1-DIOXIDE ESTERS AND INTERMEDIATES THEREFOR | PFIZER INC. (US) | 1986-11-26 | — | — | EP | disclosed |
| EP-0121383-B1 | BIS-ESTERS OF DICARBOXYLIC ACIDS WITH AMOXICILLIN AND CERTAIN HYDROXYMETHYLPENICILLANATE 1,1-DIOXIDES | PFIZER INC. (US) | 1986-05-07 | — | — | EP | disclosed |
| EP-0084925-B1 | 6-AMINOALKYLPENICILLANIC ACID 1,1-DIOXIDES AND DERIVATIVES AS BETA-LACTAMASE INHIBITORS | PFIZER INC. (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0083484-B1 | 1,1-ALKANEDIOL DICARBOXYLATE LINKED ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 1986-02-19 | — | — | EP | disclosed |
| US-4536393-A | 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor | PFIZER INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4521533-A | BACTERICIDES | PFIZER INC. (US) | 1985-06-04 | — | — | US | disclosed |
| US-4502990-A | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof | PFIZER INC. (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0128718-A1 | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof | PFIZER INC. (US) | 1984-12-19 | — | — | EP | disclosed |
| EP-0121383-A1 | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides | PFIZER INC. (US) | 1984-10-10 | — | — | EP | disclosed |
| US-4468351-A | Process for debromination of dibromopenicillanic acid and derivatives | PFIZER INC. (US) | 1984-08-28 | — | — | US | disclosed |
| US-4462934-A | BACTERICIDES FROM PENICILLINS AND PENICILLINASE INHIBITORS | PFIZER INC. (US) | 1984-07-31 | — | — | US | disclosed |
| US-4457924-A | PENICILLINS, OXAPENICILLINS, BETA-LACTAMASE INHIBITORS | PFIZER, INC. (US) | 1984-07-03 | — | — | US | disclosed |
| US-4452796-A | ANTIBIOTICS | PFIZER INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4427678-A | 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1984-01-24 | — | — | US | disclosed |
| EP-0084925-A1 | 6-Aminoalkylpenicillanic acid 1,1-dioxides and derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1983-08-03 | — | — | EP | disclosed |
| EP-0083484-A1 | 1,1-Alkanediol dicarboxylate linked antibacterial agents | PFIZER INC. (US) | 1983-07-13 | — | — | EP | disclosed |