Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PPM1B | O75688 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1087819 | 1.00 | TDP1 (0.45) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL1087816 | 1.00 | TDP1 (0.45) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL3678045 | 0.93 | CHRNB2 (0.45) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL14432884 | 0.82 | HPGD (0.32) | TDP1ALDH1A1 | |
| SCHEMBL172378 | 0.79 | TDP1 (0.52) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL8469278 | 0.78 | TDP1 (0.50) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL6952552 | 0.77 | PPM1B (0.43) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL9529692 | 0.77 | PPM1B (0.43) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL5422070 | 0.77 | PPM1B (0.43) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL5422076 | 0.77 | PPM1B (0.43) | TDP1CHRNB2CHRNA5CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190839-B1 | A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | AVEXA LTD (AU) | 2015-04-15 | — | — | EP | disclosed |
| EP-2190839-B1 | A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | AVEXA LTD (AU) | 2015-04-15 | — | — | EP | disclosed |
| US-8354546-B2 | Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes | Vertichem Corporation (CA) | 2013-01-15 | — | — | US | disclosed |
| US-8354546-B2 | Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes | Vertichem Corporation (CA) | 2013-01-15 | — | — | US | disclosed |
| US-8354546-B2 | Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes | Vertichem Corporation (CA) | 2013-01-15 | — | — | US | disclosed |
| US-8318934-B2 | Process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes | AVEXA LIMITED (AU) | 2012-11-27 | — | — | US | disclosed |
| US-8318934-B2 | Process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes | AVEXA LIMITED (AU) | 2012-11-27 | — | — | US | disclosed |
| US-8318934-B2 | Process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes | AVEXA LIMITED (AU) | 2012-11-27 | — | — | US | disclosed |
| US-20120157693-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | THESIS CHEMISTRY, LLC (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157693-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | THESIS CHEMISTRY, LLC (US) | 2012-06-21 | — | — | US | disclosed |
| US-20100305321-A1 | PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | AVEXA LIMITED (AU) | 2010-12-02 | — | — | US | disclosed |
| WO-2010068756-A3 | PROCESS FOR MANUFACTURE OF OPTICALLY ACTIVE 2-(ACYLOXYMETHYL)-1, 3 OXATHIOLANES | THESIS CHEMISTRY, LLC (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010068756-A2 | PROCESS FOR MANUFACTURE OF OPTICALLY ACTIVE 2-(ACYLOXYMETHYL)-1, 3 OXATHIOLANES | THESIS CHEMISTRY, LLC (US) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010068756-A2 | PROCESS FOR MANUFACTURE OF OPTICALLY ACTIVE 2-(ACYLOXYMETHYL)-1, 3 OXATHIOLANES | THESIS CHEMISTRY, LLC (US) | 2010-06-17 | — | — | WO | disclosed |
| US-20100143978-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | THESIS CHEMISTRY, LLC (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143978-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | THESIS CHEMISTRY, LLC (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100143978-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | THESIS CHEMISTRY, LLC (US) | 2010-06-10 | — | — | US | disclosed |
| EP-2190839-A1 | A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | Avexa Limited (AU) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009039582-A1 | A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | AVEXA LIMITED (AU) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009039582-A1 | A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | AVEXA LIMITED (AU) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157693-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | APRT, TYMP, PNP | TDP1 755/4885CHRNB2 4509/4885CHRNA5 3891/4885 |
| US-20100305321-A1 | PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES | DHPS, ICMT, ORC3 | TDP1 1225/4885CHRNB2 2665/4885CHRNA5 3294/4885 |
| US-20100143978-A1 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes | APRT, TYMP, PNP | TDP1 755/4885CHRNB2 4509/4885CHRNA5 3891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.