Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312803 | 0.89 | MMP8 (0.62) | MMP8L3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2672619 | 0.84 | MMP8 (0.54) | MMP8NPC1RAB9ALMNAHTT | |
| SCHEMBL7260547 | 0.84 | MMP8 (0.54) | MMP8LMNAHTTMEN1KMT2A | |
| SCHEMBL8233788 | 0.84 | PTPRB (0.56) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL6711568 | 0.84 | MMP8 (0.57) | MMP8LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL5752702 | 0.83 | EPHX2 (0.48) | MMP8NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL18946161 | 0.82 | MMP8 (0.59) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL5800254 | 0.82 | MMP8 (0.55) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| Hydrochloric Acid SCHEMBL20543725 | 0.82 | LMNA (0.47) | MMP8NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL7436472 | 0.81 | MMP8 (0.54) | MMP8LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075896-B1 | PHARMACEUTICAL AMIDES, AND PREPARATION, FORMULATIONS AND USE THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-02-26 | — | — | EP | disclosed |
| US-4504492-A | ENKEPHALINASE INHIBITOR | BURROUGHS WELLCOME CO. (US) | 1985-03-12 | — | — | US | disclosed |
| EP-0075896-A2 | Pharmaceutical amides, and preparation, formulations and use thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-06 | — | — | EP | disclosed |