Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436437 | 0.80 | HPGD (0.44) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10876269 | 0.80 | HPGDS (0.42) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10877089 | 0.75 | MEN1 (0.56) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10878625 | 0.74 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTPDE3BPDE3A | |
| SCHEMBL10877977 | 0.73 | PDE3B (0.46) | HPGDNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL31553388 | 0.73 | ALDH1A1 (0.64) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7434232 | 0.71 | HPGD (0.43) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2590383 | 0.66 | NPC1 (0.56) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9787284 | 0.66 | HPGD (0.43) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Ethyl Acetate SCHEMBL27923714 | 0.65 | ALDH1A1 (0.52) | HPGDNPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |