Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 6/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737609 | 0.98 | NOS2 (0.43) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL995604 | 0.93 | NOS2 (0.46) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL146828 | 0.93 | NOS2 (0.46) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL6859669 | 0.93 | NOS2 (0.46) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL28529006 | 0.88 | TSHR (0.36) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL30532399 | 0.88 | TSHR (0.36) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL31298402 | 0.87 | NOS2 (0.42) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL28310230 | 0.86 | CYP3A4 (0.35) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL10888007 | 0.85 | NOS2 (0.40) | NOS2NOS3NOS1DPP4PRCP | |
| SCHEMBL6954632 | 0.85 | TSHR (0.34) | NOS2NOS3NOS1DPP4FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4565862-A | ANTIINFLAMMATORY AGENTS;ANIMAL GROWTH REGULATORS | HOFFMANN-LA ROCHE INC. (US) | 1986-01-21 | — | — | US | claimed |
| US-4565862-A | ANTIINFLAMMATORY AGENTS;ANIMAL GROWTH REGULATORS | HOFFMANN-LA ROCHE INC. (US) | 1986-01-21 | — | — | US | disclosed |