Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | IARS1 | P41252 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10889336 | 0.72 | RAB9A (0.40) | ADORA2ATMIGD3ADORA1DAPK1PDE4A | |
| Hydrochloric Acid SCHEMBL9561683 | 0.72 | ADCY5 (0.45) | ADORA2AADORA1ADCY5CYP1A2 | |
| SCHEMBL10902555 | 0.72 | ADCY5 (0.40) | ADORA2AADCY5CYP1A2 | |
| SCHEMBL14028468 | 0.70 | ADORA2A (0.59) | ADORA2ATMIGD3ADORA1DAPK1RAB9A | |
| SCHEMBL19575388 | 0.67 | ADORA2A (0.56) | ADORA2AADORA1ADCY5 | |
| SCHEMBL7812370 | 0.64 | ADORA2A (0.63) | ADORA2AADORA1ADCY5CYP1A2ADORA2B | |
| SCHEMBL20972815 | 0.63 | ADCY5 (0.51) | ADORA2AADORA1ADCY5 | |
| SCHEMBL26212177 | 0.63 | ADORA2A (0.49) | ADORA2AADORA1ADCY5ADORA2B | |
| SCHEMBL19574922 | 0.62 | ADCY5 (0.50) | ADORA2AADORA1ADCY5 | |
| SCHEMBL19553564 | 0.62 | ADORA2A (0.61) | ADORA2AADORA1ADCY5ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077460-B1 | PURINE COMPOUNDS ENDOWED WITH IMMUNOMODULATING ACTIVITY | CO PHARMA CORPORATION S.r.l. (IT) | 1986-10-15 | — | — | EP | disclosed |
| US-4567182-A | PURINE DERIVATIVES | CO PHARMA CORPORATION S.R.L. (IT) | 1986-01-28 | — | — | US | disclosed |